HYDROPHOBIC ION-PAIRED DRUG DELIVERY SYSTEM: A REVIEW
By: Maha, Abu Hajleh
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Contributor(s): Al-Dujaili, Emad A. S.
Publisher: Mumbai Indian Drug Manufacture's Association - IDMA 2020Edition: Vol.57(01), Jan.Description: 7-18p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian drugsSummary: Hydrophobic ion-pairing (HIP) complexation technique has been displayed to modify the physicochemical properties, solubility, oral absorption, bioavailability, and the lipophilicity of an ionic drug in the lipid phase. This could affect a higher permeation through biological membranes. HIP complexation was considered through the formation of a neutral molecule by electrostatic interaction of ionizable groups of drugs with oppositely charged functional groups of a complex-forming agent. Subsequently, this ion-pair may encapsulate into many delivery systems. The objective of this manuscript was to study the effectiveness of ion-pair complextion and cover the update application of this strategy through several routes of administration such as ocular, oral, pulmonary, transdermal, and parenteral.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2020988 |
Hydrophobic ion-pairing (HIP) complexation technique has been displayed to modify the physicochemical properties, solubility, oral absorption, bioavailability, and the lipophilicity of an ionic drug in the lipid phase. This could affect a higher permeation through biological membranes. HIP complexation was considered through the formation of a neutral molecule by electrostatic interaction of ionizable groups of drugs with oppositely charged functional groups of a complex-forming agent. Subsequently, this ion-pair may encapsulate into many delivery systems. The objective of this manuscript was to study the effectiveness of ion-pair complextion and cover the update application of this strategy through several routes of administration such as ocular, oral, pulmonary, transdermal, and parenteral.
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